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While omega-3 supplements generally cause mild side effects such as bad breath and GI discomfort, they can occasionally increase the risk of bleeding when taken with medications like ibuprofen that also affect blood clotting (via Drugs.com)

More research is needed on the effects in younger people, but adult use of nicotine carries a cardiovascular risk, raises the risk of cancer and can cause bad breath, tooth loss and gum disease

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One of these harmful effects includes the impact on the digestive system , in particular on acid reflux

Effects of xylitol chewing gum on salivary flow rate and Streptococcus mutans